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The QWERTY layout became popular with the success of the Remington No. 2 of 1878, the first typewriter to include both upper and lower case letters, using a shift key.

In this section you will also find keyboard layouts that include some additional symbols of other languages. But they are different from layouts that were designed with the goal to be usable for multiple languages (see Multilingual variants).

The following sections give general descriptions of QWERTY keyboard variants along with details specific to certain operating systems. The emphasis is on Microsoft Windows.

English-speaking Canadians have traditionally used the same keyboard layout as in the United States, unless they are in a position where they have to write French on a regular basis. French-speaking Canadians respectively have favoured the Canadian French keyboard layout (see French (Canada), below).

However, with the introduction of imported computers, especially since the 1990s, the QWERTY keyboard layout is frequently used for computer keyboards. The Czech QWERTY layout differs from QWERTZ in that the characters (e.g. @$& and others) missing from the Czech keyboard are accessible with AltGr on the same keys where they are located on an American keyboard. In Czech QWERTZ keyboards the positions of these characters accessed through AltGr differs.

Germany, Austria, Switzerland, Liechtenstein, and Luxembourg use QWERTZ layouts, where the letter Z is to the right of T.

The Icelandic keyboard layout is different from the standard QWERTY keyboard because the Icelandic alphabet has some special letters, most of which it shares with the other Nordic countries: Þ/þ, Ð/ð, Æ/æ, and Ö/ö. (Æ/æ also occurs in Norwegian, Danish and Faroese, Ð/ð in Faroese, and Ö/ö in Swedish, Finnish and Estonian. In Norwegian Ö/ö could be substituted for Ø/Ø which is the same sound/letter and is widely understood).

Although rarely used, a keyboard layout specifically designed for the Latvian language called ŪGJRMV exists. The Latvian QWERTY keyboard layout is most commonly used; its layout is the same as Latin ones, but with a dead key, which allows entering special characters (āčēģīķļņõŗšūž). The most common dead key is the apostrophe ('), which is followed by Alt+Gr (Windows default for Latvian layout). Some prefer using the tick (`).

The Maltese language uses Unicode (UTF-8) to display the Maltese diacritics: ċ Ċ; ġ Ġ; ħ Ħ; ż Ż (together with à À; è È; ì Ì; ò Ò; ù Ù). There are , according to "MSA 100:2002 Maltese Keyboard Standard"; one of 47 keys and one of 48 keys. The 48-key layout is the most popular.

There are four Romanian-specific characters that are incorrectly implemented in versions of Microsoft Windows until Vista came out:

Windows Vista and newer versions include the correct diacritical signs in the default Romanian Keyboard layout.

This layout has the Z and Y keys mapped like in English layouts and also includes characters like the 'at' (@) and dollar ($) signs, among others. The older cedilla-version layout is still included albeit as the 'Legacy' layout.

Spanish keyboards are usually labelled in Spanish instead of English, its abbreviations being:

Normally "Bloq Mayús" is used instead of "Caps Lock", and "Intro" instead of "Enter".

On Linux systems, the Swedish keyboard may also give access to additional characters as follows:

Today the majority of Turkish keyboards are based on QWERTY (the so-called Q-keyboard layout), although there is also the older F-keyboard layout specifically designed for the language.

This section also tries to arrange the layouts in ascending order by the number of possible languages and not chronologically according to the Latin alphabet as usual.

The UK Extended keyboard uses mostly the AltGr key to add diacritics to the letters a, e, i, n, o, u, w and y (the last two being used in Welsh) as appropriate for each character, as well as to their capitals. Pressing the key and then a character that does not take the specific diacritic produces the behaviour of a standard keyboard. The key presses followed by spacebar generate a stand-alone mark.:

Some other languages commonly studied in the UK and Ireland are also supported to some extent:

The UK Extended layout is almost entirely transparent to users familiar with the UK layout. A machine with the extended layout behaves exactly as with the standard UK, except for the rarely used grave accent key. This makes this layout suitable for a machine for shared or public use by a user population in which some use the extended functions.

Characters with diacritics can be typed with the following combinations:

The US-International layout is not entirely transparent to users familiar with the conventional US layout; when using a machine with the international layout setting active, the commonly used single- and double-quote keys and the less commonly used grave accent, tilde, and circumflex (caret) keys are dead keys and thus behave unconventionally. This could be disconcerting on a machine for shared or public use.

There are also alternative US-International mappings, whereby modifier keys such as shift and alt are used, and the keys for the characters with diacritics are in different places from their unmodified counterparts. For example, the right-Alt key may be remapped as an AltGr modifier key or as a compose key and the dead key function deactivated, so that they (the ASCII quotation marks and circumflex symbol) can be typed normally with a single keystroke.

The Canadian Multilingual Standard keyboard layout is used by some Canadians. Though the caret (^) is missing, it is easily inserted by typing the circumflex accent followed by a space.

Unlike most of the other QWERTY layouts, which are formal standards for a country or region, EurKEY is not an EU, EFTA or any national standard.