It became the capital of major powers in ancient India, such as the Shishunaga Empire (c. 413–345 BCE), Nanda Empire (c. 460 or 420–325 BCE), the Maurya Empire (c. 320–180 BCE), the Gupta Empire (c. 320–550 CE), and the Pala Empire (c. 750–1200 CE). During the Maurya period (see below), it became one of the largest cities in the world. As per the Greek diplomat, traveler and historian Megasthenes, during the Mauryan Empire (c. 320–180 BCE) it was among the first cities in the world to have a highly efficient form of local self government. Afterwards, Sher Shah Suri (1538–1545) revived Pataliputra, which had been in decline since the 7th century CE, and renamed it Paṭna.
Extensive archaeological excavations have been made in the vicinity of modern Patna. Excavations early in the 20th century around Patna revealed clear evidence of large fortification walls, including reinforcing wooden trusses.
The etymology of Pataliputra is unclear. "Putra" means son, and "pāṭali" is a species of rice or the plant Bignonia suaveolens. One traditional etymology holds that the city was named after the plant. Another tradition says that Pāṭaliputra means the son of Pāṭali, who was the daughter of Raja Sudarshan. As it was known as Pāṭali-grāma ("Pāṭali village") originally, some scholars believe that Pāṭaliputra is a transformation of Pāṭalipura, "Pāṭali town". Pataliputra was also called Kusumapura (city of flowers).
There is no mention of Pataliputra in written sources prior to the early Jain and Buddhist texts (the Pali Canon and Āgamas), where it appears as the village of Pataligrama and is omitted from a list of major cities in the region. Early Buddhist sources report a city being built in the vicinity of the village towards the end of the Buddha's life; this generally agrees with archaeological evidence showing urban development occurring in the area no earlier than the 3rd or 4th Century BCE. In 303 BCE, Greek historian and ambassador Megasthenes mentioned Pataliputra as a city in his work Indika.Diodorus, quoting Iambulus mention that the king of Pataliputra had a " great love for the Greeks ".
Its central location in north eastern India led rulers of successive dynasties to base their administrative capital here, from the Nandas, Mauryans, Shungas and the Guptas down to the Palas.[page needed] Situated at the confluence of the Ganges, Gandhaka and Son rivers, Pataliputra formed a "water fort, or jaldurga". Its position helped it dominate the riverine trade of the Indo-Gangetic plains during Magadha's early imperial period. It was a great centre of trade and commerce and attracted merchants and intellectuals, such as the famed Chanakya, from all over India.
Two important early Buddhist councils are recorded in early Buddhist texts as being held here, the First Buddhist council immediately following the death of the Buddha and the Second Buddhist council in the reign of Ashoka. Jain and Brahmanical sources identify Udayabhadra, son of Ajatashatru, as the king who first established Pataliputra as the capital of Magadha.
During the reign of Emperor Ashoka in the 3rd century BCE, it was one of the world's largest cities, with a population of about 150,000–400,000. The city is estimated to have had a surface of 25.5 square kilometers, and a circumference of 33.8 kilometers, and was in the shape of a parallelogram and had 64 gates (that is, approximately one gate every 500 meters). Pataliputra reached the pinnacle of prosperity when it was the capital of the great Mauryan Emperors, Chandragupta Maurya and Ashoka. The city prospered under the Mauryas and a Greek ambassador, Megasthenes, resided there and left a detailed account of its splendour, referring to it as "Palibothra":
"Megasthenes says that on one side where it is longest this city extends ten miles in length, and that its breadth is one and threequarters miles; that the city has been surrounded with a ditch in breadth 600 feet, and in depth 45 feet; and that its wall has 570 towers and 64 gates." Arrian, "The Indica"
"At the confluence of the Ganges and of another river is situated Palibothra, in length 80, and in breadth 15 stadia. It is in the shape of a parallelogram, surrounded by a wooden wall pierced with openings through which arrows may be discharged. In front is a ditch, which serves the purpose of defence and of a sewer for the city." Strabo, "Geographia"
"In the royal residences in India where the greatest of the kings of that country live, there are so many objects for admiration that neither Memnon's city of Susa with all its extravagance, nor the magnificence of Ectabana is to be compared with them. (...) In the parks, tame peacocks and pheasants are kept." Aelian, "Characteristics of animals"
Under Ashoka, most of wooden structure of Pataliputra palace may have been gradually replaced by stone. Ashoka was known to be a great builder, who may have even imported craftsmen from abroad to build royal monuments. Pataliputra palace shows decorative influences of the Achaemenid palaces and Persepolis and may have used the help of foreign craftmen. Which may be the result of the formative influence of craftsmen employed from Persia following the disintegration of the Achaemenid Empire after the conquests of Alexander the Great.
The city also became a flourishing Buddhist centre boasting a number of important monasteries. It remained the capital of the Gupta dynasty (3rd–6th centuries) and the Pala Dynasty (8th-12th centuries). When Faxian visited the city in 400 A.D, he found the people to be rich and prosperous; they practised virtue and justice. He found that the nobles and householders of the city had constructed several hospitals in which the poor of all countries, the destitute, the crippled and the diseased can get treatment. They could receive every kind of help gratuitously. Physicians would inspect the diseases, and order them food, drink, and medicines. The city was largely in ruins when visited by Xuanzang, and suffered further damage at the hands of Muslim raiders in the 12th century. In a fanciful 1559 book about world geography, the Italian Caius Julius Solinus briefly mentions a powerful Indian kingdom of Prasia with a capital at Palibotra. Afterwards, Sher Shah Suri made Pataliputra his capital and changed the name to modern Patna.
During the Mauryan period, the city was described as being shaped as parallelogram, approximately 1.5 miles wide and 9 miles long. Its wooden walls were pierced by 64 gates. Archaeological research has found remaining portions of the wooden palisade over several kilometers, but stone fortifications have not been found.