The Madhyāntavibhāgakārikā (Chinese:辩中边论颂,Verses Distinguishing the Middle and the Extremes) is a key work in Buddhist philosophy of the Yogacara school attributed in the Tibetan tradition to Maitreya-nātha and in other traditions to Asanga.

The Madhyānta-vibhāga-kārikā consists of 112 verses (kārikā) which delineate the distinctions (vibhāga) and relationship between the middle (madhya) view and the extremes (anta); it contains five chapters: Attributes (laksana), Obscurations (āvarana), Reality (tattva), Cultivation of Antidotes (pratipakṣa-bhāvanā) and the Supreme Way (yānānuttarya). Along with Chinese, Tibetan and Mongolian translations, the text survives in a single Sanskrit manuscript discovered in Tibet by the Indian Buddhologist and explorer, Rahul Sankrityayan. The Sanskrit version also included a commentary (bhāsya) by Vasubandhu. An important sub-commentary (tīkā) by Sthiramati also survives in Sanskrit as well as a Tibetan version.

A Sanskrit edition was prepared by Gadjin M. Nagao in 1964.[1] The Madhyāntavibhāga-kārikā has been translated into English at least nine times, often with the Indian commentaries, in the following volumes: