She first met Thích Nhất Hạnh in 1959 and considered him her spiritual teacher. In 1963 she left for Paris to finish her degree in biology which was awarded in 1964.
She returned to Vietnam later that year and joined Thích Nhất Hạnh in founding the Van Hanh University.
From 1969 to 1972 Chân Không worked with Thích Nhất Hạnh in Paris organizing the Buddhist Peace Delegation which campaigned for peace in Vietnam. She then worked with Thích Nhất Hạnh to establish the first the Sweet Potato community near Paris, then Plum Village Monastery in 1982. Chân Không accompanied and assisted Thích Nhất Hạnh when he traveled. In addition, she has organized relief work for those in need in Vietnam, by coordinating relief food parcels for poor children and medicine for the sick, and has helped organize activities at Plum Village.