In five-dimensional geometry, a 5-cube is a name for a five-dimensional hypercube with 32 vertices, 80 edges, 80 square faces, 40 cubic cells, and 10 tesseract 4-faces.

It is a part of an infinite hypercube family. The dual of a 5-cube is the 5-orthoplex, of the infinite family of orthoplexes.

Applying an alternation operation, deleting alternating vertices of the 5-cube, creates another uniform 5-polytope, called a 5-demicube, which is also part of an infinite family called the demihypercubes.

The 5-cube can be seen as an order-3 tesseractic honeycomb on a 4-sphere. It is related to the Euclidean 4-space (order-4) tesseractic honeycomb and paracompact hyperbolic honeycomb order-5 tesseractic honeycomb.

This configuration matrix represents the 5-cube. The rows and columns correspond to vertices, edges, faces, cells, and 4-faces. The diagonal numbers say how many of each element occur in the whole 5-cube. The nondiagonal numbers say how many of the column's element occur in or at the row's element.[1][2]

The Cartesian coordinates of the vertices of a 5-cube centered at the origin and having edge length 2 are

while this 5-cube's interior consists of all points (x0, x1, x2, x3, x4) with -1 < xi < 1 for all i.

n-cube Coxeter plane projections in the Bk Coxeter groups project into k-cube graphs, with power of two vertices overlapping in the projective graphs.

This polytope is one of 31 uniform 5-polytopes generated from the regular 5-cube or 5-orthoplex.